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Botanical Name :
Leptadenia reticulata
Sanskrit Name: Jivanti, Jivani, Madhusrava
English Name : Jivanti, jiwanti
Family : Asclpiadaceae
Part used: leaf
Sanskrit Name: Jivanti, Jivani, Madhusrava
English Name : Jivanti, jiwanti
Family : Asclpiadaceae
Part used: leaf
Description of
Leptadenia reticulata:
It grows in the sub-Himalayan tracts of Punjab, U.P. and throughout the Deccan Peninsula up to an altitude of 900 m, in India.
L.reticulata is a much-branched twining shrub. The bark is yellowish brown, corky, deeply cracked; the leaves are ovate-cordate, coriaceous glabrous above, more or less finely pubescent beneath; the flowers are in many-flowered cymes, greenish yellow; the follicles are sub-woody and turgid.
It grows in the sub-Himalayan tracts of Punjab, U.P. and throughout the Deccan Peninsula up to an altitude of 900 m, in India.
L.reticulata is a much-branched twining shrub. The bark is yellowish brown, corky, deeply cracked; the leaves are ovate-cordate, coriaceous glabrous above, more or less finely pubescent beneath; the flowers are in many-flowered cymes, greenish yellow; the follicles are sub-woody and turgid.
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Principal Constituents:
The plant contains a triterpenoid, leptadenol (C30H50O). It also contained n -triacontane, cetyl alcohol, ß-sitosterol, ß-amyrin acetate, lupanol 3-O -diglucoside and leptidin.
The plant contains a triterpenoid, leptadenol (C30H50O). It also contained n -triacontane, cetyl alcohol, ß-sitosterol, ß-amyrin acetate, lupanol 3-O -diglucoside and leptidin.
Pharmacology:
A number of studies have been carried out on the galactagogue property of the plant in laboratory animals. Studies on the lactogenic property of L.reticulata were carried out on lactating rats using pup weight, body weight of mother rats, and histopathological study of lactating mammary gland, as well as the secretory rating, parenchyma percentage, estimation of glycogen content (of the abdominal mammary glands) and the protein content (of the pectoral mammary glands) as parameters. While both stigmasterol and the ether fraction of L.reticulata showed lactogenic effect, as assessed by all these parameters, stigmasterol was found to be more potent2.A herbal preparation with L.reticulata as one of the nine constituents is said to exert beneficial effects on the gametogenic and androgenic functions of the testes of animals. It showed anabolic cum androgen like activity as evidenced by the dose related growth of the ventral prostate and the systemic increase in the weights as well as the secretions of the accessory sex organs of castrated adult mice.
A number of studies have been carried out on the galactagogue property of the plant in laboratory animals. Studies on the lactogenic property of L.reticulata were carried out on lactating rats using pup weight, body weight of mother rats, and histopathological study of lactating mammary gland, as well as the secretory rating, parenchyma percentage, estimation of glycogen content (of the abdominal mammary glands) and the protein content (of the pectoral mammary glands) as parameters. While both stigmasterol and the ether fraction of L.reticulata showed lactogenic effect, as assessed by all these parameters, stigmasterol was found to be more potent2.A herbal preparation with L.reticulata as one of the nine constituents is said to exert beneficial effects on the gametogenic and androgenic functions of the testes of animals. It showed anabolic cum androgen like activity as evidenced by the dose related growth of the ventral prostate and the systemic increase in the weights as well as the secretions of the accessory sex organs of castrated adult mice.
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Clinical Studies:
The lactogenic/galactagogue effect of L.reticulata has been clinically assessed by many investigators. These studies have been mainly carried out on the commercial preparation of Leptaden.
The lactogenic/galactagogue effect of L.reticulata has been clinically assessed by many investigators. These studies have been mainly carried out on the commercial preparation of Leptaden.
Toxicity:
On acute toxicity studies, L.reticulata (aqueous extract) and leptaden administered orally for three alternate days, and three consecutive days to rats, were safely tolerated up to a dose of 3.125 g/kg. An increase in dose led to an increase in mortality. Post mortem, subcutaneous peticheal hemorrhage was noted, whilst the liver, kidney and heart showed no apparent change.
On acute toxicity studies, L.reticulata (aqueous extract) and leptaden administered orally for three alternate days, and three consecutive days to rats, were safely tolerated up to a dose of 3.125 g/kg. An increase in dose led to an increase in mortality. Post mortem, subcutaneous peticheal hemorrhage was noted, whilst the liver, kidney and heart showed no apparent change.
Indications:
The plant is stimulant and restorative and shows anti-bacterial activity against gram-positive and gram-negative bacteria.
The plant is stimulant and restorative and shows anti-bacterial activity against gram-positive and gram-negative bacteria.
LEPTADENIA
RETICULATA ( JEEVANTHI )
|
|
| PRODUCT CODE: | NE/LR/063 |
DESCRIPTION
|
BROWNISH
COLOURED POWDER WITH BITTER TASTE
|
IDENTIFICATION
|
T.L.C. COMPARISON WITH RAW MATERIAL
|
SOLUBILITY
WATER |
SOLUBLE |
NATURE OF EXTRACT
|
DRY
EXTRACT
|
HERB EXT. RATIO
|
10 : 1
|
| OTHERS | % OF ALKALOID = 0.21% |
| WATER SOLUBLE EXTRACTIVES AS PER I.P. 66 | 84% |
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*Disclaimer
"These statements have not been evaluated by the food and drug administration or any other regulatory body. These products are not intended to diagnose, treat, cure, or prevent any
disease.
"These statements have not been evaluated by the food and drug administration or any other regulatory body. These products are not intended to diagnose, treat, cure, or prevent any
disease.
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